Selecting for Functional Alternative Splices in ESTs

Selecting for functional alternative splices in ESTs.

The expressed sequence tag (EST) collection in dbEST provides an extensive resource for detecting alternative splicing on a genomic scale. Using genomically aligned ESTs, a computational tool (TAP) was used to identify alternative splice patterns for 6400 known human genes from the RefSeq database. With sufficient EST coverage, one or more alternatively spliced forms could be detected for nearl...

Automatic Detection of Comma Splices

In English text, independent clauses should be demarcated with full-stops (periods), or linked together with conjunctions. Non-native speakers are often prone to linking them improperly with commas instead of conjunctions, producing comma splices. This paper describes a method to detect comma splices using Conditional Random Fields (CRF), with features derived from parse tree patterns. In exper...

A novel tenascin type III repeat is part of a complex of tenascin mRNA alternative splices

Sequence analysis of two human tenascin encoding cDNA clones from a cDNA library of the U251 glioblastoma cell line revealed the presence of a novel 276 bp tenascin type III fibronectin like repeat. This alternatively spliced type III repeat designated AD1 is located between the previously identified repeats 10 and 11 and has sequence homology with human, chicken and mouse tenascin type III rep...

Micky: A Cheaper Alternative for Selecting Cloud Instances

Most cloud computing optimizers explore and improve one workload at a time. When optimizing many workloads, the single-optimizer approach can be prohibitively expensive. Accordingly, we examine “collective optimizer” that concurrently explore and improve a set of workloads significantly reducing the measurement costs. Our large-scale empirical study shows that there is often a single cloud conf...

Mechanics of Bolted Electrical Splices